Candida tropicalis distribution and drug resistance is correlated with ERG11 and UPC2 expression
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چکیده
منابع مشابه
Regulation of efflux pump expression and drug resistance by the transcription factors Mrr1, Upc2, and Cap1 in Candida albicans.
Constitutive overexpression of the Mdr1 efflux pump is an important mechanism of acquired drug resistance in the yeast Candida albicans. The zinc cluster transcription factor Mrr1 is a central regulator of MDR1 expression, but other transcription factors have also been implicated in MDR1 regulation. To better understand how MDR1-mediated drug resistance is achieved in this fungal pathogen, we s...
متن کاملExpression of Lanosterol 14-Demethylase (ERG11) Gene of Three-Drug Combinations in Candida albicans
Patients with impaired immunity are at particular risk of infections with Candida albicans. Antifungal drugs such as azoles commonly used for candidiasis treatment, but drug resistance is one of the most common problems for public health. The aim of this study was to evaluate the expression of lanosterol 14-demethylase (ERG11) gene for three-drug combinations in C. albicans. Disk diffusion and ...
متن کاملStudy and detection of ERG11 gene mutation in resistant - drug Candida albicans and relation with Iranian women infertility
Aim and Background: Candida Albicans is the most important cause of vulvovaginal candidiasis and resistance to azoles can occur via various mechanisms including, change in the ERG11 gene. This study aim was to identification of ERG11 gene mutations in drug resistant Candida albicans isolated from patients with Candida vaginitis and its association with infertility in Iranian women. Mat...
متن کاملA gain-of-function mutation in the transcription factor Upc2p causes upregulation of ergosterol biosynthesis genes and increased fluconazole resistance in a clinical Candida albicans isolate.
In the pathogenic yeast Candida albicans, the zinc cluster transcription factor Upc2p has been shown to regulate the expression of ERG11 and other genes involved in ergosterol biosynthesis upon exposure to azole antifungals. ERG11 encodes lanosterol demethylase, the target enzyme of this antifungal class. Overexpression of UPC2 reduces azole susceptibility, whereas its disruption results in hyp...
متن کاملCandida tropicalis: its prevalence, pathogenicity and increasing resistance to fluconazole.
Candida tropicalis has been identified as the most prevalent pathogenic yeast species of the Candida-non-albicans group. Historically, Candida albicans has been the major species responsible for causing candidiasis in immunocompromised and immunocompetent patients. However, infections (candidiasis) due to C. tropicalis have increased dramatically on a global scale thus proclaiming this organism...
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ژورنال
عنوان ژورنال: Antimicrobial Resistance & Infection Control
سال: 2021
ISSN: 2047-2994
DOI: 10.1186/s13756-021-00890-2